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KMID : 1103720120670050341
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Journal of the Korean Society of Radiology
2012 Volume.67 No. 5 p.341 ~ p.348
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CT Densitometry of the Lung in Healthy Nonsmokers with Normal Pulmonary Function
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Oh Tack-Sun
Chae Eun-Jin
Seo Joon-Beom
Jung Young-Ju
Oh Yeon-Mok
Lee Sang-Do
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Abstract
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Purpose: To investigate the upper normal limit of low attenuation area% in healthy nonsmokers.
Materials and Methods: A total of 36 nonsmokers with normal pulmonary function test underwent a CT scan. Six thresholds (-980 - -930 HU) on inspiration CT and two thresholds (-950 and -910 HU) on expiration CT were used for obtaining low attenuation area%. The mean lung density was obtained on both inspiration CT and expiration CT. Descriptive statistics of low attenuation area% and the mean lung density, evaluation of difference of low attenuation area% and the mean lung density in both sex and age groups, analysis of the relationship between demographic information and CT parameters were performed.
Results: Upper normal limit for low attenuation area% was 12.96% on inspiration CT (-950 HU) and 9.48% on expiration CT (-910 HU). Upper normal limit for the mean lung density was -837.58 HU on inspiration CT and 686.82 HU on expiration CT. Low attenuation area% and the mean lung density showed no significant differences in both sex and age groups. Body mass index (BMI) was negatively correlated with low attenuation area% on inspiration CT (-950 HU, r = -0.398, p = 0.016) and positively correlated with the mean lung density on inspiration CT (r = 0.539, p = 0.001) and expiration CT (r = 0.432, p = 0.009). Age and body surface area were not correlated with low attenuation area% or the mean lung density.
Conclusion: Low attenuation area% on CT densitometry of the lung could be found in healthy nonsmokers with normal pulmonary function, and showed negative association with BMI. Reference values, such as range and upper normal limit for low attenuation area% in healthy subjects could be helpful in quantitative analysis and follow up of early emphysema, using CT densitometry of the lung.
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KEYWORD
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Pulmonary Disease, Chronic Obstructive, Respiratory Function Test, Tomography, X-Ray Computed
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